TABLE 4.
DFRs in the genome of Y. pestis
| DFR | Gene region | Annotated function | Gene(s) selected for PCR-based screening |
|---|---|---|---|
| 01 | 91001-pMT044-047 | Ribonucleoside-diphosphate reductase and hypothetical proteins | 91001-pMT045 |
| 02 | 91001-pMT086-094 | C-type natriuretic protein and hypothetical proteins | 91001-pMT092 |
| 03 | CO92-YPMT1.03c-1.12c | Prophage | CO92-YPMT1.07c |
| 04 | 91001-YP0966-YP0986 | RNA helicase, multidrug transport system, two-component regulatory system, and transcriptional regulators | 91001-YP0975 |
| 05 | CO92-YPO0621-0636 | Regulatory proteins, hypothetical proteins, and aminotransferase | CO92-YPO0626 |
| 06 | CO92-YPO0738-0739 | Flagellins | CO92-YPO0739 |
| 07 | CO92-YPO0740-0754 | Flagellins and membrane proteins | CO92-YPO0744 |
| 08 | CO92-YPO0988-0989 | Membrane protein | CO92-YPO0988 |
| 09 | CO92-YPO0998-1007 | Membrane proteins, autotransporter, antigenic leucine-rich repeat proteins, and drug efflux proteins | CO92-YPO1003 |
| 10 | CO92-YPO1165-1172 | Dehydrogenase, regulatory proteins, xanthosine utilization | CO92-YPO1167 |
| 11 | CO92-YPO1986-1987 | Exported protein | CO92-YPO1987 |
| 12 | CO92-YPO2096-2135 | Prophage | CO92-YPO2098, YPO2115 |
| 13 | CO92-YPO2271-2281 | Prophage | CO92-YPO2273 |
| 14 | CO92-YPO2286-2287 | Transport system permease | CO92-YPO2287 |
| 15 | CO92-YPO2315 | Exported protein | CO92-YPO2315 |
| 16 | CO92-YPO2375-2376 | Aldo/keto reductase | CO92-YPO2375 |
| 17 | CO92-YPO2380 | Insecticial toxin | CO92-YPO2380 |
| 18 | CO92-YPO2469 | Conserved hypothetical protein | CO92-YPO2469 |
| 19 | CO92-YPO2487-2489 | Membrane protein and hypothetical proteins | CO92-YPO2489 |
| 20 | CO92-YPO3046-3047 | Sulfatase | CO92-YPO3047 |
| 21 | CO92-YPO3674 | Insecticidal toxin | CO92-YPO3674 |
| 22 | CO92-YPO4012-4045 | Two-component regulatory system, membrane proteins, amino acid utilization, iron transport system, regulatory proteins, sugar transport system, and fimbriae | CO92-YPO4019, -YPO4040 |