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. 2015 Jul 27;10(7):e0134084. doi: 10.1371/journal.pone.0134084

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© 2015 Ganu et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 1 — The phylogeny was inferred from an amino acid alignment using maximum likelihood implemented in RAxML [31]. Bootstrap supports are indicated at nodes and were based on 500 pseudoreplicates. We have labeled non-mammalian BHMT, mammalian BHMT and mammalian BHMT2. Note that a duplication event resulted in the appearance of BHMT2 at the base of the mammalian lineage, since BHMT and BHMT2 are both present in all extant placental mammals. The relatively long branches in BHMT2 following the duplication event suggest an accelerated evolutionary rate following a change in evolutionary constraints related to the functional divergence between BHMT and BHMT2.