Table 1.
Area under the curve (AUC) values from ROC analysis and p-values of Wilcoxon rank sum test for N-glycans derived from human blood serum of sex- and age-matched control and esophageal cancer patients. Highlighted rows are the N-glycans which received a highly accurate ROC analysis AUC values (AUC > 0.8) and low p-values of Wilcoxon rank sum test, while others are N-glycans which received a moderately accurate ROC analysis AUC values (0.7<AUC<0.8) and low p-values of Wilcoxon rank sum test. Values listed in red indicate a decrease in the relative intensity of N-glycans derived from esophageal adenocarcinoma samples.
| Control vs. Cancer | |||||
|---|---|---|---|---|---|
| Glycan [M+Na]+ Theoretical | Glycan [M+Na]+ Observed | ppm | Structure | P-value | ROC AUC |
| 2244.13 | 2244.12 | −2 |
|
2.60E-09 | 0.99±0.01 |
| 2040.03 | 2040.03 | 1 |
|
2.10E-07 | 0.95±0.03 |
| 2227.11 | 2227.12 | 3 |
|
1.81E-08 | 0.90±0.04 |
| 2605.30 | 2605.30 | 2 |
|
4.67E-05 | 0.88±0.05 |
| 2070.04 | 2070.03 | −3 |
|
4.13E-07 | 0.87±0.06 |
| 3950.96 | 3950.92 | −10 |
|
6.70E-05 | 0.86±0.06 |
| 1906.96 | 1906.96 | −2 |
|
1.10E-05 | 0.84±0.06 |
| 2635.99 | 2635.96 | −13 |
|
1.96E-08 | 0.82±0.06 |
| 1590.80 | 1590.80 | −1 |
|
4.45E-07 | 0.79±0.08 |
| 1794.90 | 1794.90 | −1 |
|
1.17E-05 | 0.79±0.08 |
| 2274.14 | 2274.14 | 4 |
|
8.43E-06 | 0.77±0.08 |
| 2214.11 | 2214.10 | −7 |
|
2.22E-05 | 0.76±0.07 |
| 2029.01 | 2029.02 | 6 |
|
1.67E-07 | 0.76±0.07 |
| 1620.81 | 1620.81 | −2 |
|
2.49E-06 | 0.75±0.07 |
| 1764.89 | 1764.86 | −15 |
|
0.000151645 | 0.74±0.08 |
| 2431.21 | 2431.21 | 1 |
|
0.006978279 | 0.74±0.08 |