Table 8.
Comparison of innate differences in gene expression between iP and iNP rats and effects of EtOH self-administration by iP rats on gene expression in the nucleus accumbens
| Gene description | iP vs iNP | EtOH vs SAC & water |
|---|---|---|
| Proteolipid protein | Plp (+) | Plp (+) |
| Adenosine monophosphate deaminase/adenosine deaminase | Ampd3 (+) | Adar (−) |
| 3-phosphoglycerate dehydrogenase/glycerol-3-phosphate dehydrogenase | Phgdh (−) | Gdp1 (+) |
| Beta-2 microglobulin | B2m (−) | B2m (+) |
| ATPase, Ca++ transporting, plasma membrane | Atp2a2 (−) | Atp2b4 (−) |
| Guanine nucleotide binding protein alpha | Gnao (−) | Gnaq (−) |
| Homer homolog 1, 2 (Drosophila) | Homer2 (−) | Homer1 (+) |
| Microtubule-associated proteins tau, 1A/1B light chain 3, 1b | Mapt (−); Map1lc3b (+) | Map1b (−) |
| Casein kinase 1 delta/epsilon | Csnk1d (−) | Csnk1e (−) |
| Synaptogamin 6 | Syt6 (−) | Syt6 (−) |
| Albumin | Alb (+) | Alb (+) |
| Ferritin heavy/light chain 1 | Fth1 (+) | Ftl1 (+) |
| Gamma-aminobutyric acid receptor subunit beta 1, 2 | Gabrb1 (+) | Gabrb2 (−) |
| Response gene to complement 32 | Rgc32 (+) | Rgc32 (+) |
| Synaptic vesicle glycoprotein 2b, 2a | Sv2b (+) | Sv2a (+) |
| Protein kinase C, alpha, delta, gamma | Prkcd (+) Prkcg (+) |
Prkca (−) |
Plus (+) symbol indicates higher expression in iP compared to iNP or higher expression in EtOH group versus SAC and Water groups; minus (−) symbol indicates the opposite.