. 2015 Jul 27;10(7):e0132853. doi: 10.1371/journal.pone.0132853

Table 3. Survival prior to matching: prognosis factors in univariate and multivariate analyses.

		OS				DDFS
		Univariate		Multivariate		Univariate		Multivariate
		HR [CI 95%]	p-value	HR [CI 95%]	p-value	HR [CI 95%]	p-value	HR [CI 95%]	p-value
Years of diagnosis	1981–1983	1	.	1	.	1	.	1	.
	1984–1988	0.85 [0.80–0.91]	<0.0001	0.89 [0.70–1.13]	0.33	0.89 [0.82–0.97]	0.009	1.01 [0.76–1.34]	0.95
	1989–1993	0.75 [0.71–0.81]	<0.0001	0.87 [0.69–1.10]	0.25	0.86 [0.79–0.93]	0.0002	0.97 [0.74–1.28]	0.86
	1994–1998	0.67 [0.62–0.72]	<0.0001	0.77 [0.61–0.98]	0.03	0.75 [0.69–0.82]	<0.0001	0.82 [0.62–1.08]	0.16
	1999–2003	0.51 [0.47–0.56]	<0.0001	0.68 [0.51-.092]	0.01	0.56 [0.51–0.62]	<0.0001	0.61 [0.44–0.84]	0.0002
	2004–2008	0.38 [0.35–0.42]	<0.0001	0.42 [0.32–0.55]	<0.0001	0.41 [0.37–0.46]	<0.0001	0.44 [0.32–0.59]	<0.0001
Age (years)	< 35	1.47 [1.31–1.65]	<0.0001	1.42 [1.00–2.02]	0.05	2.01 [1.88–2.35]	<0.0001	1.64 [1.24–2.16]	0.0005
	35 to 49	0.86 [0.82–0.91]	<0.0001	1.15 [0.96–1.37]	0.13	1.21 [1.14–1.27]	<0.0001	1.14 [1.01–1.29]	0.03
	50 to 65	1	.	1	.	1	.	1	.
	> 65	2.25 [2.15–2.37]	<0.0001	2.06 [1.85–2.30]	<0.0001	1.00 [0.94–1.06]	0.99	1.09 [0.9–1.25]	0.17
Menopausal status	post-menopausal	1	.	1	.	1	.	1	.
Menopausal status	pre-menopausal	0.62 [0.59–0.65]	<0.0001	0.68 [0.57–0.80]	<0.0001	1.23 [1.17–1.29]	<0.0001	.	NS
BMI (kg/m²)	< 18.5	0.96 [0.83–1.11]	0.57	1.25 [1.02–1.52]	0.03	0.92 [0.79–1.09]	0.38	1.16 [0.93–1.45]	0.20
	[18.5–25[	1	.	1	.	1	.	1	.
	[25–30[	1.29 [1.20–1.39]	<0.0001	1.13 [1.01–1.25]	0.03	1.18 [1.09–1.27]	<0.0001	1.09 [0.97–1.22]	0.16
	≥ 30	1.49 [1.35–1.65]	<0.0001	1.22 [1.05–1.41]	0.008	1.31 [1.18–1.46]	<0.0001	1.22 [1.04–1.43]	0.01
Histological type	Ductal	1	.	1	.	1	.	1	.
	Lobular	1.07 [1.00–1.14]	0.04	.	NS	1.08 [1.00–1.16]	0.04	.	NS
	Other	1.05 [0.99–1.10]	0.1	.	NS	0.95 [0.88–1.01]	0.11	.	NS
Histological tumor size	pT1	1	.	1	.	1	.	1	.
	pT2	2.17[2.06–2.28]	<0.0001	1.47 [1.34–1.63]	<0.0001	2.54 [2.39–2.70]	<0.0001	1.66 [1.49–1.84]	<0.0001
	pT3	3.18 [2.81–3.59]	<0.0001	2.26 [1.83–2.80]	<0.0001	3.94 [3.44–4.50]	<0.0001	2.20 [1.76–2.75]	<0.0001
	pT4	2.53 [1.61–3.97]	<0.0001	1.65 [0.73–3.73]	0.23	2.93 [1.89–4.56]	<0.0001	2.34 [1.27–4.29]	0.006
Involved axillary nodes	0	1	.	1	.	1	.	1	.
	1 to 3	1.54 [1.47–1.63]	<0.0001	1.22 [1.09–1.36]	0.0006	1.96 [1.85–2.08]	<0.0001	1.47 [1.31–1.67]	<0.0001
	4 to 9	2.94[2.76–3.13]	<0.0001	2.14 [1.85–2.48]	<0.0001	4.47 [4.18–4.78]	<0.0001	2.93 [2.52–3.42]	<0.0001
	≥ 10	4.81 [4.43–5.22]	<0.0001	3.38 [2.75–4.15]	<0.0001	7.75 [7.12–8.44]	<0.0001	5.52 [4.54–6.72]	<0.0001
SBR grade	1	1	.	1	.	1	.	1	.
	2	1.56 [1.47–1.66]	<0.0001	1.09 [0.96–1.24]	0.20	2.16 [2.00–2.33]	<0.0001	1.61 [1.37–1.89]	<0.0001
	3	2.41 [2.27–2.56]	<0.0001	1.84 [1.63–2.08]	<0.0001	3.69 [3.43–3.98]	<0.0001	2.68 [2.31–3.12]	<0.0001
Hormone receptor status	Hormone receptor +	1	.	1	.	1	.	1	.
Hormone receptor status	Hormone receptor -	1.55 [1.47–1.64]	<0.0001	1.34 [1.18–1.52]	<0.0001	1.65 [1.56–1.74]	<0.0001	1.26 [1.10–1.44]	0.0007
Adjuvant chemotherapy	No	1	.	1	.	1	.	1	.
Adjuvant chemotherapy	Yes	0.89 [0.84–0.96]	<0.0001	0.88 [0.78–1.00]	0.05	1.41 [1.34–1.49]	<0.0001	0.85 [0.74–0.97]	0.01

OS: overall survival. DDFS: Distant disease-free survival. BMI: body mass index. pT1: pathological tumor size ≤ 2 cm. pT2: tumor > 2 cm and ≤ 5 cm. pT3: > 5 cm. pT4: extension to skin and/or chest wall. SBR: Scarff Bloom and Richardson. HR: hazard ratio. NS: not significant in multivariate analysis and therefore not included in the final multivariate model.