Table 3. Results of the meta-analysis for dichotomous outcomes.
| Outcomes | Group or Subgroup | Set of data | N patients, RC/LC | Analysis model / Effect measure | I2 | Summary Statistics | 95% CI | P value |
|---|---|---|---|---|---|---|---|---|
| Conversion to open | Total | 13 | 584/981 | FE/ OR | 20% | 0.67 | 0.39 to 1.15 | 0.15 |
| Total * | 13 | 584/981 | FE/ RD | 21% | -0.02 | -0.04 to 0.00 | 0.13 | |
| Right colon | 8 | 334/549 | FE/ OR | 0% | 0.38 | 0.17 to 0.87 | 0.02 | |
| Right colon * | 8 | 334/549 | FE/ RD | 45% | -0.03 | -0.06 to -0.01 | 0.02 | |
| Left colon | 3 | 115/240 | FE/ OR | 1% | 0.87 | 0.29 to 2.57 | 0.80 | |
| Cancer | 6 | 304/531 | FE/ OR | 25% | 0.91 | 0.40 to 2.05 | 0.81 | |
| Cancer * | 6 | 304/531 | FE/ RD | 1% | -0.00 | -0.03 to 0.02 | 0.72 | |
| Overall postoperative complications | Total | 13 | 584/982 | FE/OR | 0% | 0.74 | 0.57 to 0.95 | 0.02 |
| Right colon | 8 | 334/550 | FE/ OR | 4% | 0.70 | 0.50 to 0.96 | 0.03 | |
| Left colon | 3 | 115/240 | FE/ OR | 0% | 0.64 | 0.32 to 1.29 | 0.21 | |
| Cancer | 6 | 304/531 | FE/ OR | 15% | 0.62 | 0.43 to 0.90 | 0.01 | |
| Anastomotic leak | Total | 13 | 584/981 | FE/ OR | 0% | 0.70 | 0.37 to 1.30 | 0.26 |
| Total* | 13 | 584/981 | FE/ RD | 0% | -0.01 | -0.03 to 0.01 | 0.20 | |
| Right colon | 8 | 334/549 | FE/ OR | 16% | 0.76 | 0.31 to 1.86 | 0.55 | |
| Right colon* | 8 | 334/549 | FE/ RD | 28% | -0.01 | -0.03 to 0.02 | 0.51 | |
| Left colon | 3 | 115/240 | FE/ OR | 0% | 0.31 | 0.05 to 1.84 | 0.20 | |
| Cancer | 6 | 304/531 | FE/ OR | 0% | 0.58 | 0.26 to 1.29 | 0.18 | |
| Postoperative ileus | Total | 12 | 609/3212 | FE/ OR | 0% | 0.71 | 0.48 to 1.05 | 0.08 |
| Total * | 12 | 609/3212 | FE/ RD | 3% | -0.02 | -0.05 to 0.00 | 0.06 | |
| Right colon | 8 | 334/549 | FE/ OR | 0% | 0.54 | 0.28 to 1.06 | 0.07 | |
| Right colon * | 8 | 334/549 | FE/ RD | 18% | -0.03 | -0.06 to 0.00 | 0.05 | |
| Left colon | 3 | 115/240 | RE/ OR | 77% | 1.56 | 0.05 to 47.03 | 0.80 | |
| Left colon * | 3 | 115/240 | FE/ RD | 37% | 0.00 | -0.04 to 0.05 | 0.92 | |
| Cancer | 4 | 169/339 | RE/ OR | 71% | 1.04 | 0.08 to 13.66 | 0.98 | |
| Cancer * | 4 | 169/339 | RE/ RD | 67% | -0.01 | -0.07 to 0.04 | 0.67 | |
| Wound Infection | Total | 13 | 584/981 | FE/ OR | 0% | 0.59 | 0.35 to 0.99 | 0.04 |
| Total * | 13 | 584/981 | FE/ RD | 0% | -0.02 | -0.05 to -0.00 | 0.03 | |
| Right colon | 8 | 334/549 | FE/ OR | 0% | 0.67 | 0.36 to 1.26 | 0.21 | |
| Right colon* | 8 | 334/549 | FE/ RD | 0% | -0.02 | -0.05 to 0.01 | 0.21 | |
| Left colon | 3 | 115/240 | FE/ OR | 0% | 0.50 | 0.15 to1.62 | 0.25 | |
| Cancer | 6 | 304/531 | FE/ OR | 0% | 0.54 | 0.26 to 1.14 | 0.11 | |
| Cancer* | 6 | 304/531 | FE/ RD | 0% | -0.03 | -0.06 to 0.00 | 0.07 |
FE: Fixed Effect; RE: Random Effect; OR: Odds Ratio; RD: Risk Difference; CI: Confidence interval
*: Analysis performed with the Risk Difference (RD) as a summary statistic to also include in the estimated effect the studies with dichotomous outcomes with 0 events in each of the treatment groups.