Table 1a.

Basal Activity (GOF).

Receptor	BW	Mutation	Size	Charge	Hydrophicity	Ref.
TSHR	1.49	G → S	Increased		More hydrophilic	19, 152
MC4R	1.49	E → K		− → +		153
TSHR LHCGR	2.43	M → T	Decreased		More hydrophilic	19, 59, 154
						19, 60, 155, 156
TSHR	3.43	L → Q	Increased		More hydrophilic	25, 157
TSHR LHCGR	3.43	L → R	Increased		More hydrophilic	19, 63
						19, 64, 74
TSHR	5.54	V → F	Increased			158
TSHR	5.54	V → L	Increased			159
LHCGR	5.54	I → L				14, 19
TSHR, FSHR	6.30	D → G	Decreased	− → neutral		13, 19, 160, 161
						15, 19
LHCGR, FSHR	6.30	D → N		− → neutral		14, 19
						19, 162, 163, 164
TSHR	6.34	A → I	Increased			13, 19, 160
TSHR, LHCGR	6.34	A → V	Increased			19, 160, 161, 165, 166
						19, 167
TSHR	6.34	A → F	Increased			62
TSHR, LHCGR	6.37	M → I	Decreased			19, 168
						19, 169
TSHR, LHCGR	6.38	A → V	Increased			170
						19, 171
TSHR	6.40	L → F	Increased			18, 19, 61
TSHR, MC4R	6.40	L → Q	Increased		More hydrophilic	18, 19, 61
						19, 46, 48, 172, 173
TSHR	6.41	I → M	Increased			174
TSHR, LHCGR	6.41	I → L				19, 175
						19, 176
TSHR, LHCGR	6.43	T → I	Increased		More hydrophobic	19, 161, 177, 178, 179
						19, 169
TSHR	6.44	D → A	Decreased	− → neutral		18, 19
TSHR, LHCGR	6.44	D → E	Increased			18, 19, 178, 179
						19, 180
TSHR, LHCGR	6.44	D → Y	Increased	− → neutral		18, 19, 161, 178, 179, 181
						14, 19, 36
LHCGR	6.44	D → G	Decreased	− → neutral		19, 182, 183
LHCGR	6.44	D → H		− → +		19, 36