Table 2.

Transduction ability.

	Receptor	BW	Mutation	Ref.
G protein binding pocket	V2R	3.50	R → H	73
	MC4R	3.53	T → I	48
	LHCGR	6.34	A → V	167
	FSHR	6.36	R → C	188
	LHCGR	7.55	I → K	25, 74, 189
Central cluster	MC4R	2.50	D → N	190
	V2R	2.50	D → N	191, 192, 193
	MC4R	3.40	I → T	194
	LHCGR	3.43	L → R	64
	MC4R	6.43	V → I	172, 184, 195
	LHCGR	6.45	C → R	14
	TSHR	7.45	N → S	196
	V2R	7.50	P → S	75
Cluster helices I and II	V2R	1.39	L → F	197
	LHCGR	1.41	L → P	198
	MC4R	1.43	G → D	153
	MC4R	1.43	G → V	153
	FSHR	2.61	A → T	199
	MC4R	2.62	I → S	184
Outliners	MC4R	4.51	A → T	49, 195
	LHCGR	6.59	A → P	76