Table 3.

Ligand binding affinity.

GOF: Decreased KD				LOF: Increased KD
Receptor	Mutation	BW	Ref.	Receptor	Mutation	BW	Ref.
LHCGR	M → T	2.43	19, 60, 155, 156	MC4R	E → K	1.49	153
TSHR	M → V	2.53	19, 200	MC4R	N → S	1.50	25, 49, 173, 184, 201
TSHR	S → R	3.36	19, 160, 196	MC4R	N → D	2.57	25, 49, 173, 195
TSHR	V → A	3.40	19, 160, 202, 203	MC4R	L → P	2.66	25, 173, 201
TSHR	Y → N	5.58	19, 204	V2R	R → W	3.26	192, 205, 206, 207, 208
TSHR	D → G	6.30	13, 19, 160	MC4R	I → K	3.28	25, 49, 173, 185, 195
TSHR	A → I,V	6.34	13, 19, 160, 165, 166	MC4R	I → T	3.40	25, 172, 173, 194
MC4R	L → Q	6.40	19, 46, 48, 172, 173	V2R	Y → C	5.39	191, 208, 209, 210
TSHR	L → F	6.40	18, 19, 61	V2R	P → H	7.50	75
TSHR	I → M	6.41	174
TSHR	F → L	6.42	19, 211
TSHR	T → I	6.43	19, 178, 179
TSHR	C → W	6.47	212
MC4R	F → S	6.51	95
MC4R	I → T	7.52	48, 172