Table 2.
Highlights of results from GO enrichment analyses on gene modules whose expressions are more similar between IA- and RR-WCR populations.
| Module # | Size* | Overall anova sig.† | Significant factor(s) | Process‡ | Function | ||
|---|---|---|---|---|---|---|---|
| GO term ID | Description | GO term ID | Description | ||||
| J | 69 | 1.4E-02 | Phenotype, Diet | 0045861 | Negative regulation of proteolysis | 0004867 | Serine-type endopeptidase inhibitor activity |
| 0051346 | Negative regulation of hydrolase activity | 0080019 | Fatty-acyl-CoA reductase (alcohol-forming) activity | ||||
| 0043455 | Regulation of secondary metabolic process | 0004180 | Carboxypeptidase activity | ||||
| K | 32 | 2.4E-02 | Phenotype, Diet | 0071616 | Acyl-CoA biosynthetic process | 0015645 | Fatty acid ligase activity |
| 0035383 | Thioester metabolic process | 0016877 | Ligase activity, forming carbon-sulfur bonds | ||||
| L | 682 | 4.0E-06 | Phenotype, Diet, interaction | 1901605 | Alpha-amino acid metabolic process | 0003824 | Catalytic activity |
| 0006082 | Organic acid metabolic process | 0016742 | Hydroxymethyl-, formyl- and related transferase activity | ||||
| 0044281 | Small molecule metabolic process | 0019238 | Cyclohydrolase activity | ||||
| M | 129 | 3.9E-04 | Phenotype, Diet, interaction | 0055085 | Transmembrane transport | 0046873 | Metal ion transmembrane transporter activity |
| 0005215 | Transporter activity | ||||||
| 0004553 | Hydrolase activity, hydrolyzing O-glycosyl compounds | ||||||
| N | 27 | 2.6E-04 | Phenotype, Diet, interaction | 1900073 | Regulation of neuromuscular synaptic transmission | 0000981 | Sequence-specific DNA binding RNA polymerase II transcription factor activity |
| 0070050 | Neuron homeostasis | 0001077 | RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription | ||||
| 0007254 | JNK cascade | 0043565 | Sequence-specific DNA binding | ||||
ND, No enriched GO terms detected.
*
Number of isotigs/contigs included in each gene module.
†
Overall anova tests on the eigengene values of each module; significance threshold: P < 0.1.
‡
Results from the gene list analyses using GOrilla were summarized with REViGO by removing redundant GO terms. Three GO terms with the lowest P-values (from the summarized results) were reported for each gene module. The significance threshold was set at 0.001 (default setting).