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. 2015 Jun 3;181(2):219–229. doi: 10.1111/cei.12643

Figure 4.

Figure 4

Interleukin (IL)-22BP expression in the salivary glands of patients with primary Sjögren’s syndrome (pSS patients). Relative m-RNA quantification of IL-22BP (a) was assessed by quantitative reverse transcription–polymerase chain reaction (qRT–PCR) in salivary glands obtained from 30 pSS patients and non-Sjögren’s syndrome patients (nSS). (b–d) Representative microphotographs showing IL-22BP immunostainings in pSS (b–d) and nSS (e) subjects. IL-22BP expression was weakly observed among infiltrating mononuclear cells scattering in the inflammatory infiltrates, being observable only in few mononuclear cells distributed in the proximity of ducts (d, arrows). A clear IL-22BP expression was observed in ductal epithelial cells and in the lumen ducts (b–d). (e) No significant IL-22BP immunoreactive cells were observed in nSS subjects. (f) Representative paraffin sections of salivary glands of pSS patients stained with rabbit immunoglobulins (isotype control). (b) Original magnification ×100; (c–f) Original magnification ×250.