Table 5.
Characteristics of three severe antibody deficiency patients with a persistent viral infection
| Antibody deficiency | Patient 1‡CVID | Patient 2†CVID | Patient 3†CVID | |
|---|---|---|---|---|
| Virus | Norovirus genotype 2 | Norovirus genotype 2 | Norovirus genotype 2 | Rhinovirus |
| Months of infection | 9 | 30 | 16 | 11 |
| Virus clearance | Yes | No | No | Yes |
| Number of positive results | 13 | 12 | 29 | 10 |
| Number of negative results since clearance | 1 | – | – | 13 |
| At the time of first positive result | ||||
| IgG (5·5–16·5) | 10.0 | 13·9 | 8·7 | 9·1 |
| IgA (0·8–4·0) | 0·06 | 0·14 | <0·04 | <0·04 |
| IgM (0·4–2·0) | <0·06 | 1·36 | 0·45 | 0·45 |
| Lymphocyte count × 109/l | 1·2 | 1·4 | 8·1 | 9·5 |
| CD3+ count × 106/l (918–2023) | 971 | 720 | 9974 | 8927 |
| CD4+ count × 106/l (455–1820) | 402 | 466 | 2668 | 2750 |
| CD8+ count × 106/l (140–906) | 577 | 261 | 7109 | 5892 |
| CD56+ count × 106/l (90–600) | 94 | 122 | 345 | 278 |
Reference ranges are shown in parentheses. CVID = common variable immune deficiency; Ig = immunoglobulin.
Lymphocyte count reference ranges: †(1·2–3·5) × 109/l ‡(1·5–4·0) × 109/l.