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. 2015 May 19;181(2):343–356. doi: 10.1111/cei.12635

Figure 3.

Figure 3

Increased apoptosis in the spleen upon ABT-737 treatment. (a–c) Interleukin (IL)-10−/− mice suffering from spontaneous colitis. (a) Decreased number of CD8+ splenocytes in Il10−/− upon ABT-737 compared to vehicle determined by flow cytometry. Number of CD4+ and CD8+ splenocytes in Bim−/− × Il10−/− remained unchanged upon ABT-737. Statistical analysis was performed using the Mann–Whitney rank-sum test, P < 0·05 (*). (b) Decreased number of CD8+ splenocytes in Il10−/− upon ABT-737 compared to vehicle determined by flow cytometry. (c) Mass cytometric analysis of T cell receptor (TCR)β+ splenocytes revealed a significantly decreased proportion of CD3+CD8+ T cells upon ABT-737 compared to vehicle. Statistical analysis was performed using the Holm–Sidak method, P < 0·05 (*).