Figure 5.

Mice suffering from colitis develop an ameliorated intestinal inflammation upon ABT-737 treatment compared to vehicle-receiving mice. (a,b) Il10^−/− mice suffering from spontaneous colitis. (a) Representative images demonstrate colonoscopy pictures derived from ABT-737- and vehicle-treated mice. (b) Statistical analysis of colonoscopy score [murine endoscopic index of colitis severity (MEICS)]. Normality test was passed and statistical analysis was performed using one way analysis of variance (anova) (Bonferroni t-test). Colonoscopy was performed on the day prior to killing the animals. Box-plots express median, 95/5% percentiles and outliers, P < 0·05 (*).