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. 2009 Jun 11;13(9b):3006–3018. doi: 10.1111/j.1582-4934.2009.00824.x

Figure 1.

Figure 1

Modes of UPS involvement in regulation of DNA repair. *Abbreviations: O6meG, O6-methylated guanine; MGMT, O6-methylguanine-DNA methyltransferase; DR, direct repair; hMSH2, human MutS homologue 2; hMSH6, human MutS homologue 6; hMLH1, human MutL homologue 1; hPMS2, human post-meiotic segregation increased 2 protein; MMR, mismatch-repair; NEDD8, neural precursor cell expressed, developmentally down-regulated 8; EXO I, human exonuclease 1; SSBs, single-strand breaks; DSBs, double-strand breaks; TDG, thymine-DNA glycosylase; APE, apurinic endonuclease; Lig 3, DNA-ligase 3; FEN1, flap structure-specific endonuclease 1; BER, base-excision repair; NER, nucleotide-excision repair; GGR, global genomic repair; TCR, transcription-coupled repair; CSN, COP9 signalosome; SUMO, small ubiquitin-like modifier; UNG2, uracil-DNA glycosylase 2; PARP-1, poly-ADP-ribose polymerase; XRCC1, X-ray repair complementing defective repair in Chinese hamster cells 1; XPC, Xeroderma pigmentosum complementation group C; HR23, homologue of Rad23; DDB1, damage-specific DNA binding protein 1; DDB2, damage-specific DNA binding protein 2; NEDD8, neural precursor cell expressed developmentally down-regulated 8; XPG, Xeroderma pigmentosum complementation group G; XPF, Xeroderma pigmentosum complementation group F; ERCC1, excision repair cross-complementing rodent repair deficiency complementation group 1; Lig 1, DNA-ligase 1; HR, homologous recombination; NHEJ, non-homologous end joining; XRCC4, X-ray repair complementing defective repair in Chinese hamster cells 4; Lig 4, DNA-ligase 4; DNA-PKcs, DNA-dependent protein kinase catalytic subunit; PCNA, proliferating cell nuclear antigen protein; DSBR, double-strand break repair; MRN, Mre11-Rad50-Nbs1 complex; RPA, replication protein A; BRCA 1,2, breast cancer 1,2 genes; XRCC2, X-ray repair complementing defective repair in Chinese hamster cells 2; XRCC3; X-ray repair complementing defective repair in Chinese hamster cells 3; XRCC4, X-ray repair complementing defective repair in Chinese hamster cells 4; PRR, post-replication repair; TLS, translesion DNA synthesis; Pol η, DNA polymerase η; Pol ζ, DNA polymerase ζ; Pol γ, ɛ, DNA polymerases γ, ɛ; FANCC, Fanconi anaemia, complementation group C; FANCD2, Fanconi anaemia complementation group D2; FANCI, Fanconi anaemia complementation group I.