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. 2009 Feb 20;13(9b):3236–3250. doi: 10.1111/j.1582-4934.2009.00714.x

Figure 2.

Figure 2

Compared to control, COX-1 and COX-2 inhibitors potently and efficaciously reduced SRC. Examples of a SRC that is maintained for 100 min. and unaffected by time and DMSO (A; expanded time scale of ‘inset’ reveals individual rhythmic contractions) and a SRC that is nearly abolished by the cumulative addition of increasing concentrations of the COX-2 inhibitor, NS-398 (B). Note that the x-axis time scale in the ‘inset’ of (A) shows the time-expanded region from which the data were extracted. Summary data for protocols shown in (B) for the COX-2 inhibitors, NS-398 and LM-1685 (C) and the COX-1 inhibitors, SC-560 and FR-122047 (FR-122) (D). Open symbols in (C) and (D) show the small average decline in SRC over time and in the presence of DMSO. Data in (C) and (D) are means ± S.E., n= 4–9. *=P < 0.05 compared to DMSO control.