Table 1.

Phenotypes of patients carrying the 10 MC4R mutations studied in the current report

Mutation	Prevalence (%)	BMI	Age of obesity onset	References
R7C	0.02*	28.5	Unknown	[21]
C84R	0.35†	26.2	13	[22]
S127L	0.25†	Unknown	Unknown	[23]
S136F	0.98†	33.2	2.3	[24]
W174C	0.51‡	59.0	8.0	[25]
A219V	0.13‡	Unknown	Unknown	[26]
P230L	0.12†	Unknown	Unknown	[23]
F261S	0.39‡	36.8	1.0	[27]
I317V	0.51‡	39.2	10.0	[25]
L325F	0.13‡	Unknown	Unknown	[26]

BMI, body mass index.

^*From population-based samples.

^†From obese children and adolescents.

^‡From obese adults.