Table 3.
Comparison of the immunogenicity of HESC-derived NPC and foetal ReNcell-VM cell line
| HESC-NPC | ReNcell-VM | |||
|---|---|---|---|---|
| IFN-γ | 0 | 1000 U/ml | 0 | 1000 U/ml |
| aCostimulatory molecules | − | − | − | − |
| bNon-classical HLA | − | − | − | − |
| MHC I | − | +++ | − | +++ |
| MHC II | − | − | − | − |
| cMLR | + | +++ | + | +++ |
| NK-cell killing | +++ | +++ | +++ | +++ |
| MIC A/B | + | + | ++ | ++ |
| ULBP-1 | + | + | + | ++ |
| ULBP-2 | + | + | + | + |
| ULBP-3 | + | ++ | + | ++ |
| NK killing after blocking of NKG2D and its ligands | + | + | + | + |
| NK killing with immunosuppressants | +++ | +++ | +++ | +++ |
| Inhibition of neuronal differentiation with immunosuppressants | ++ | nd | +++ | nd |
a
CD40, CD80,CD86, B7H1.
b
HLA-G, HLA-E.
c
Mixed lymphocyte reaction.
nd, not done.