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. 2010 Jan 29;13(9b):3668–3679. doi: 10.1111/j.1582-4934.2009.00661.x

Figure 3.

Figure 3

The affects of SHP1 expression on JAK2/STAT3/STAT5 protein levels in CRC cells. CRC cells transfected with pEGFP-N1 or pEGFP-N1-SHP1 were sorted for GFP expression and extracts analysed by Western blot. Substantial decreases in expression of pJAK2, JAK2, pSTAT3 and pSTAT5 were detected. The decrease in pJAK2 levels was greater than that of JAK2. In contrast, no significant changes in STAT3 and STAT5 protein levels were detected. The data shown are from a representative experiment and detection of GAPDH was used as a loading control.