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. 2009 Feb 20;13(9b):3960–3972. doi: 10.1111/j.1582-4934.2009.00708.x

Figure 4.

Figure 4

Changes in melanoma cell expression of cMyc on incubation with UNBS1450 or anti-α1 siRNA. (A) The kinetics of the decrease in cMyc expression in VM-21 (Aa) and SKMEL-28 (Ab) cells in the presence of UNBS1450 (10 and 100 nM) were evaluated by Western blot up to 48 hrs. Tubulin was used as the loading control. (B) Immunofluorescent staining of sodium pump α1 and cMyc protein in VM-21 cells either untreated (control) or transfected with the anti-α1 siRNA 3 days before the experiment. The decrease in α1 sub-unit expression is associated with a marked decrease in cMyc expression. The corresponding bright-field pictures are provided.