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. 2009 Feb 20;13(9b):3960–3972. doi: 10.1111/j.1582-4934.2009.00708.x

Figure 6.

Figure 6

In vivo effects of UNBS1450 treatment in a human melanoma brain metastatic model. (A) Typical histology of melanoma brain metastases developed when grafting VM-48 cells into the brain of nude mice (HE; GX50). T: tumour and NB: normal brain tissue. Higher magnification (G × 100) is provided in (B). Black arrows point to infiltrative tumour cells in the normal brain parenchyma. (C) Kaplan–Meier survival analysis of VM-48-bearing mice either left untreated (control group: black circles) or treated with dacarbazine (DTIC: open squares: 80 mg/kg i.p.), temozolomide (open diamonds: 40 mg/kg i.v.) or UNBS1450 (open circles: 1 mg/kg i.v.) administered three times per week for 3 weeks.