Table 1.
Immunohistochemical expression of α1 sub-units in clinical naevi and melanoma samples
Diagnosis | Histological or clinical data | No. of cases analyzed | No. of positive cases | Staining intensity | Area stained (%) | |||
---|---|---|---|---|---|---|---|---|
+ | ++ | (min-max) | mean | |||||
Naevi | Dermal | 20 | 2/20 | 2 | 0 | 20–40 | 30 | |
Junctional | 11 | 0/11 | 0 | 0 | 0 | 0 | ||
Mixt | 23 | 1/23 | 1 | 0 | 10 | 10 | ||
Lentigo | 3 | 0/3 | 0 | 0 | 0 | 0 | ||
TOTAL | 57 | 3/57 | 3 | 0 | 10–40 | 23 | ||
Melanomas | SSM | 26 | 5/26 | 1 | 4 | 15–80 | 42 | |
NM | 3 | 1/3 | 1 | 0 | 30 | 30 | ||
Acral | 5 | 1/5 | 1 | 0 | 80 | 80 | ||
Dubreuil | 10 | 1/10 | 1 | 0 | 50 | 50 | ||
Metastases | Lymph nodes | 9 | 2/9 | 0 | 2 | 25–75 | 50 | |
Brain | 18 | 13/18 | 1 | 12 | 10–80 | 73 | ||
Others | 11 | 4/11 | 2 | 2 | 25–75 | 53 | ||
Breslow | <1 mm | 18 | 0/18 | 0 | 0 | 0 | 0 | |
1–2 mm | 8 | 1/8 | 1 | 0 | 50 | 50 | ||
2–4 mm | 8 | 3/8 | 1 | 2 | 25–30 | 28 | ||
>4 mm | 10 | 4/10 | 2 | 2 | 15–80 | 59 | ||
Total | 82 | 27/82 | 7 | 20 | 10–80 | 57 |