Table 1.
Baseline demographics and treatment assignment by genotype
| Met/Met n=17 |
Met/Val or Val/Val n=64 |
Total n=81 |
df | f | p | |
|---|---|---|---|---|---|---|
| Categorical variables | ||||||
| Assigned to CBT4CBTa, number (%) | 8 (47.1) | 30 (46.9) | 38 (46.9) | 1 | 0 | 0.99 |
| Treatment as usual (TAU)b | 9 (52.9) | 34 (53.1) | 43 (53.1) | |||
| Number (%) female | 11 (64.7) | 41 (64.1) | 52 (64.2) | 1 | 0.00 | 0.96 |
| Race | ||||||
| Caucasian | 13 (76.5) | 37 (57.8) | 50 (61.7) | 1 | 3.06 | 0.38 |
| African-American | 4 (23.5) | 19 (29.7) | 23 (28.4) | |||
| Hispanic | 0 (0) | 7 (10.9) | 7 (8.6) | |||
| Multiracial | 0 (0) | 1 (1.6) | 1 (1.2) | |||
| Completed high school | 13 (76.5) | 45 (70.3) | 58 (71.6) | 1 | 0.25 | 0.62 |
| Unmarried or living alone | 17 (100) | 56 (87.5) | 73 (90.1) | 1 | 2.36 | 0.12 |
| Unemployed | 16 (94.1) | 57 (89.1) | 73 (90.1) | 1 | 0.39 | 0.54 |
| Referred by criminal justice system | 1 (5.9) | 12 (18.8) | 13 (16) | 1 | 1.65 | 0.20 |
| On public assistance | 15 (88.2) | 50 (78.1) | 65 (80.2) | 1 | 0.87 | 0.35 |
| Lifetime alcohol use disorder2 | 12 (70.6) | 47 (74.6) | 59 (73.8) | 1 | 0.11 | 0.74 |
| Lifetime major depression | 6 (35.3) | 30 (31.3) | 26 (32.1) | 1 | 0.10 | 0.75 |
| Continuous variables (mean + standard deviation) | ||||||
| Methadone dose at baseline | 92.9+28.2 | 81.4+26.1 | 83.9+26.8 | 1,78 | 2.51 | 0.12 |
| Days paid for work in past 28 | 1.8+5.4 | 2.4+5.5 | 2.3+5.5 | 1,79 | 0.15 | 0.70 |
| Age | 43.7+9.2 | 42.1+9.6 | 42.4+9.5 | 1,79 | 0.39 | 0.54 |
| Days of cocaine use, past 28 | 11.7+9.4 | 15.2+9.1 | 14.5+9.2 | 1,79 | 1.93 | 0.17 |
| Days of heroin use, past 28 | 1.8+4.9 | 1.8+5.2 | 1.8+5.1 | 1,79 | 0.00 | 0.97 |
| Days of marijuana use, past 28 | 3.5+7.5 | 2.8+6.9 | 3.0+7.0 | 1,79 | 0.15 | 0.70 |
| Days of cigarette use, past 28 | 26.4+6.8 | 25.4+7.8 | 25.6+7.6 | 1,79 | 0.21 | 0.64 |
| Days of alcohol use, past 28 | .4+.5 | .4+.5 | .4+.5 | 1,79 | 0.39 | 0.54 |
| Age of first cocaine use | 19.7+5.5 | 19.6+5.0 | 19.6+5.1 | 1,79 | 0.01 | 0.94 |
| Years of regular cocaine use | 12.4+6.0 | 12.0+9.4 | 12.1+8.8 | 1,79 | 0.02 | 0.90 |
| ASIc Medical Composite | .53+.39 | .37+.38 | .40+.38 | 1,79 | 2.48 | 0.12 |
| ASI Employment Composite | .74+.28 | .79+.23 | .78+.24 | 1,79 | 0.61 | 0.44 |
| ASI Alcohol Composite | .04+.07 | .05+.13 | .05+.12 | 1,79 | 0.10 | 0.75 |
| ASI Cocaine Composite | .67+.18 | .64+.25 | .65+.24 | 1,79 | 0.15 | 0.70 |
| ASI Legal Composite | .06+.17 | .08+.16 | .07+.16 | 1,79 | 0.10 | 0.75 |
| ASI Family Composite | .15+.19 | .10+.12 | .11+.14 | 1,79 | 2.27 | 0.14 |
| ASI Psychological Composite | .17+.23 | .15+.19 | .15+.20 | 1,79 | 0.24 | 0.62 |
| Shipley IQ | 101.7+12.3 | 97.1+11.3 | 97.9+11.6 | 1,74 | 1.98 | 0.16 |
Note.
a
CBT4CBT indicates computerized cognitive behavioral therapy plus standard treatment.
b
TAU indicates standard methadone maintenance treatment.
c
ASI indicates Addiction Severity Index; composite scores range from 0 to 1, where higher scores indicate severity/higher level of problems.