Table 4.
Proteins significantly down-regulated in PR8-infected ATII cells
| Uniprot ID | Protein Name | Number of Peptides Identified |
Fold Change1 (P-value) |
|---|---|---|---|
| Cell Death and Stress Response | |||
| Q60930 | Voltage-dependent anion channel 2 | 21 | 0.80 (0.042) |
| Q60932 | Voltage-dependent anion channel 1 | 6 | 0.71 (0.002) |
| Q01853 | Transitional endoplasmic reticulum ATPase | 5 | 0.51 (0.044) |
| Q69ZN7 | Myoferlin | 5 | 0.63 (0.008) |
| Q6P069 | Sorcin | 2 | *(0.014) |
| Q8R1V4 | ER stress response protein 25 | 2 | 0.64 (0.049) |
| Proteolysis | |||
| P49722 | Proteasome, subunit, alpha type 2 | 17 | 0.76 (0.032) |
| O55234 | Proteasome, subunit, beta type 5 | 13 | 0.66 (0.017) |
| P57716 | Nicastrin | 3 | 0.57 (0.002) |
| P17047 | Lysosomal-associated membrane protein 2 | 2 | 0.25 (0.014) |
| Chromatin Formation and DNA Damage Response | |||
| P62806 | Histone H4 | 55 | 0.68 (0.026) |
| Q9D2U9 | Histone H2ba, H2bb | 34 | 0.87 (0.025) |
| Q9QZQ8 | Core histone H2A.1 | 5 | 0.62 (0.001) |
| O54962 | Barrier to autointegration factor 1 | 2 | 0.72 (0.008) |
| Mitochondrial | |||
| P43024 | Cytochrome c oxidase, subunit VI | 6 | 0.5 (0.023) |
| Q8BW75 | Monoamine oxidase B | 6 | 0.64 (0.016) |
| Q9CZ13 | Ubiquinol-cytochrome c reductase core protein 1 | 5 | 0.69 (0.005) |
| Q9CPQ8 | ATP synthase, H+ transporting, mitochondrial F0 complex | 4 | 0.55 (0.02) |
| Q99JR1 | Sideroflexin 1 | 4 | 0.61 (0.037) |
| Q99JB2 | Stomatin (Epb7.2)-like 2 | 4 | 0.72 (0.002) |
| Q9R112 | Sulfide quinone reductase-like (yeast) | 3 | 0.52 (0.01) |
| Q9Z2Z6 | Mitochondrial carnitine/acylcarnitine translocase, 20 | 3 | 0.52 (0.018) |
| Q9DCS9 | NADH dehydrogenase 1 beta subcomplex, 10 | 3 | 0.6 (0.028) |
| O55126 | Protein NipSnap homolog 2 | 3 | 0.66 (0.037) |
| Q8BGH2 | Sorting and assembly machinery component 50 | 3 | 0.68 (0.017) |
| Q921G7 | Electron transferring flavoprotein, dehydrogenase | 2 | *(0.014) |
| Q9DCJ5 | NADH dehydrogenase 1 alpha subcomplex, 8 | 2 | 0.52 (0.013) |
| Q8R127 | Saccharopine dehydrogenase (putative) | 2 | 0.56 (0.002) |
| Q9D855 | Ubiquinol-cytochrome c reductase binding protein | 2 | 0.71 (0.005) |
| Q9D0M3 | Cytochrome c-1 | 2 | 0.73 (0.002) |
| Cell Signaling and Adhesion | |||
| Q8R2Y2 | Melanoma cell adhesion molecule MUC18 | 6 | 0.5 (0.006) |
| Q61490 | Activated leukocyte cell adhesion molecule | 6 | 0.64 (0.002) |
| P11688 | Integrin alpha 5 (fibronectin receptor alpha) | 4 | 0.60 (0.002) |
| Q07113 | Insulin-like growth factor 2 receptor | 3 | *(0.014) |
| Lipids and Polysaccharides Metabolism | |||
| Q8C166 | Copine I | 11 | 0.67 (0.029) |
| P50405 | Surfactant-associated protein B | 8 | 0.37 (<0.001) |
| Q64435 | UDP glucuronosyltransferase 1–6 | 6 | 0.78 (0.05) |
| Q80UM7 | Mannosyl-oligosaccharide glucosidase | 2 | *(0.014) |
| Other Metabolism | |||
| P22437 | Prostaglandin-endoperoxide synthase 1 | 2 | 0.44 (0.007) |
| Miscellaneous Transmembrane | |||
| Q9DBS1 | Transmembrane protein 43 | 11 | 0.77 (0.037) |
| Q8VCM8 | Nicalin | 2 | 0.47 (0.002) |
1
Fold change expressed as ratio of signal intensity in PR8-infected/mock
P-value determined by Student’s t-test, or
*
G-test when not detected in PR8