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. Author manuscript; available in PMC: 2016 Sep 5.
Published in final edited form as: Mol Cell Endocrinol. 2015 May 21;412:226–238. doi: 10.1016/j.mce.2015.05.008

Figure 8.

Figure 8

A hypothetical model of regulatory pathways involved in Xlr5c-like expression and potential function of Xlr5c-like in granulosa cells of rat periovulatory follicles. hCG increases transcription of the Xlr5c-like gene by activating signaling molecules including PKA, MAPK, MEK and PI3K. At the promoter level, PGR, RUNX1 and SP3 are involved in transcriptional activation of the Xlr5c-like gene. In turn, Xlr5c-like affects the expression of specific ovulatory genes such as Snap25, Cxcr4, and Adamts1.