Table 4.
Multivariable Associations between Logarithmic of Serum Cotinine Levels and BOT-2 Subtests.
| BOT-2 Subtests | Explanatory Variables | β ( 95% CI) | P | Adj. R2 |
|---|---|---|---|---|
| Fine motor precision | Serum cotinine | −0.09 (−0.22, 0.05) | 0.21 | |
| Age | 0.70 (0.46, 0.94) | <0.0001 | ||
| Gender | −1.14 (−1.58, −0.70) | <0.0001 | ||
| Barratt’s Education | 0.10 (−0.002, 0.20) | 0.05 | ||
| Blood Pb | −0.32 (−0.83, 0.18) | 0.21 | 0.24 | |
| BMn (Linear) | 13.80 (0.85, 26.75) | 0.04 | ||
| BMn (Quadratic) | −3.07 (−5.92, −0.21) | 0.03 | ||
| HMn (Linear) | 0.001 (−0.26, 0.26) | 0.99 | ||
| Fine motor integration | Serum cotinine | −0.09 (−0.17, −0.02) | 0.01 | |
| Age | 0.22 (0.08, 0.36) | 0.002 | ||
| Gender | −0.32 (−0.57, −0.07) | 0.01 | 0.10 | |
| Barratt’s Education | 0.02 (−0.03, 0.08) | 0.40 | ||
| HMn (Linear) | 0.02 (−0.13, 0.17) | 0.80 | ||
| Manual dexterity | Serum cotinine | −0.04 (−0.11, 0.03) | 0.26 | |
| Age | 0.54 (0.40, 0.67) | <.0001 | ||
| Gender | −0.32 (−0.56, −0.08) | 0.01 | ||
| BMI | −0.02 (−0.05, 0.02) | 0.36 | ||
| Parent IQ | 0.003 (−0.01, 0.01) | 0.51 | 0.24 | |
| BPb | 0.06 (−0.23, 0.34) | 0.69 | ||
| BMn (Linear) | 11.10 (4.02, 18.18) | 0.002 | ||
| BMn (Quadratic) | −2.44 (−4.00, −0.88) | 0.002 | ||
| HMn (Linear) | 1.72 (0.39, 3.04) | 0.01 | ||
| HMn (quadratic) | −0.14 (−0.25, −0.03) | 0.01 | ||
| Bilateral coordination | Serum cotinine | −0.03 (−0.09, 0.04) | 0.40 | |
| Age | 0.31 (0.19, 0.43) | <0.0001 | ||
| Gender | −0.32 (−0.54, −0.11) | 0.003 | 0.18 | |
| Barratt’s Education | 0.10 (0.05, 0.15) | <0.0001 | ||
| HMn (Linear) | 0.06 (−0.07, 0.18) | 0.37 | ||
| Balance | Serum cotinine | −0.07 (−0.13, −0.01) | 0.02 | |
| Gender | −0.23 (−0.43, −0.03) | 0.04 | ||
| BMI | −0.04 (−0.07, −0.01) | 0.003 | ||
| Barratt’s Education | −0.04 (−0.08, 0.01) | 0.13 | 0.08 | |
| Blood Mn (Linear) | 7.48 (1.57, 13.39) | 0.01 | ||
| Blood Mn (Quadratic) | −1.66 (−2.96, −0.36) | 0.01 | ||
| Hair Mn (Linear) | 0.08 (−0.03, 0.20) | 0.16 | ||
| Running speed | Serum cotinine | −0.03 (−0.13, 0.07) | 0.57 | |
| Age | 0.26 (0.08, 0.44) | 0.006 | ||
| BMI | −0.11 (−0.16, −0.06) | <0.001 | ||
| Parent IQ | −0.004 (−0.02, 0.01) | 0.52 | ||
| Barratt’s Education | 0.03 (−0.06, 0.12) | 0.49 | 0.13 | |
| Blood Pb | 0.05 (−0.33, 0.43) | 0.79 | ||
| Blood Mn (Linear) | 13.44 (3.88, 22.99) | 0.006 | ||
| Blood Mn (Quadratic) | −3.04 (−5.14, −0.93) | 0.004 | ||
| Hair Mn (Linear) | 1.20 (−0.58, 2.99) | 0.19 | ||
| Hair Mn (Quadratic) | −0.09 (−0.24, 0.05) | 0.19 | ||
| Upper limb coordination | Serum cotinine | −0.12 (−0.31, 0.06) | 0.19 | |
| Age | 1.03 (0.70, 1.36) | <.0001 | ||
| Barratt’s Education | 0.09 (−0.05, 0.23) | 0.19 | 0.15 | |
| Blood Pb | 0.83 (0.14, 1.53) | 0.02 | ||
| Hair Mn (Linear) | 0.26 (−0.09, 0.61) | 0.15 | ||
| Strength | Serum cotinine | −0.14 (−0.28, −0.001) | 0.04 | |
| Age | 1.15 (0.88, 1.42) | <.0001 | ||
| BMI | −0.14 (−0.22, −0.07) | 0.001 | ||
| Parent IQ | 0.007 (−0.01, 0.03) | 0.44 | 0.25 | |
| BPb | 0.22 (−0.35, 0.80) | 0.45 | ||
| Blood Mn (Linear) | 20.63 (6.16, 35.10) | 0.005 | ||
| Blood Mn (Quadratic) | −4.60 (−7.79, −1.41) | 0.005 | ||
| Hair Mn (Linear) | 0.21 (−0.07, 0.50) | 0.14 |