Table 2. Diagnostic laboratory test results of patients with mediastinal masses, according to final diagnosis.
| Overall (N=131) | Benign (N=104) | Malignant (N=27) | Univariable OR (95% CI) | Univariable P value | |
|---|---|---|---|---|---|
| Mean WBC/mm3 | 10,067 (6,082) | 9,898 (6,320) | 10,622 (5,306) | 0.98 (0.92-1.05) | 0.59 |
| Mean ANC/mm3 | 5,984 (4,270) | 5,380 (3,924) | 7,932 (4,810) | 1.00 (1.00-1.00) | 0.010 |
| Leukocytosis* | 34/111† (31) | 24/84 (29) | 10/34 (37) | 0.68 (0.27-1.70) | 0.41 |
| Neutropenia** | 3/108 (3) | 3/81 (4) | 0/27 (0) | ∞ | 0.57 |
| Mean ALC/mm3 | 2,425 (1,370) | 2,678 (1,354) | 1,609 (1,090) | 1.00 (1.00-1.00) | <0.001 |
| Lymphopenia** | 10/108 (9) | 0/81 (0) | 10/27 (37) | 0.00 | <0.001 |
| Mean Hct (g/dL) | 35.6 (5.2) | 35.6 (4.8) | 35.37 (6.2) | 1.01 (0.93-1.10) | 0.75 |
| Anemia | 69/110 (63) | 48/83 (58) | 21/27 (78) | 0.39 (0.14-1.07) | 0.07 |
| Mean platelet count (×103/mm3) Thrombocytosis | 389 (136) | 371 (123) | 436 (165) | 1.00 (0.99-1.00) | 0.04 |
| Thrombocytosis | 39/109 (36) | 27/83 (33) | 12/26 (46) | 0.56 (0.23-1.38) | 0.21 |
| Thrombocytopenia | 0/109 (0) | 0/83 (0) | 0/26 (0) | 0.00 | |
| Mean LDH (U/L) | 434 (264) | 458 (278) | 385 (231) | 1.00 (1.00-1.00) | 0.24 |
| Elevated LDH | 44/80 (55) | 32/53 (60) | 12/27 (44) | 1.90 (0.75-4.86) | 0.18 |
| Mean uric acid (mg/dL) | 4.3 (1.5) | 4.0 (1.1) | 4.7 (2.1) | 0.75 (0.54-1.04) | 0.09 |
| Elevated UA | 4/73 (5) | 1/46 (2) | 3/27 (11) | 0.18 (0.02-1.80) | 0.14 |
| Mean ESR (mm/hr) | 50 (35) | 47 (34) | 56 (39) | 0.99 (0.98-1.01) | 0.45 |
| Elevated ESR | 38/51 (75) | 27/37 (73) | 11/14 (79) | 0.74 (0.17-3.20) | 0.68 |
| Mean CRP (mg/dL) | 7.8 (10.0) | 7.7 (10.8) | 8.2 (6.9) | 64 (0.27-11.00) | 0.61 |
| Elevated CRP | 50/57 (88) | 37/43 (86) | 13/14 (93) | 0.47 (0.05-4.32) | 0.51 |
Data are presented as mean (SD) and No. (%)
*
Determination of low or high values based on age-related limits at the two institutions with the exception of ANC and ALC defined below
**
Neutropenia and lymphopenia defined as <1000 cells/mcl
†
no./No.
Abbreviations: ALC, absolute lymphocyte count; ANC, absolute neutrophil count; ALT, serum alanine aminotransferase concentration; AST, serum aspartate aminotransferase concentration; Cr, serum creatinine concentration; ESR, erythrocyte sedimentation rate; CRP, C-reactive protein; LDH, serum lactate dehydrogenase; UA, serum uric acid; WBC, white blood count