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. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: Virology. 2015 May 15;483:117–125. doi: 10.1016/j.virol.2015.02.035

Table 3A.

The effect of anti-G protein mAb 131-2G and anti-F protein 143-6C treatment on Pro inflammatory cytokine/chemokine levels in r19F RSV infected mice

Untreated mAb 131-2G treated mAb 143-6C treated
Days (pi) Pro inflammatory Cytokines/chemokines pg/gram of lung pg/gram of lung pg/gram of lung
4 MIP-1α 20.45±3.17 14.60±3.46* 18.33±2.18
MCP-1 16.04±2.08 13.24±3.87* 15.72±2.45
IL-1α 42.87±5.36 25.96±4.43** 27.53±3.12**
IL-1β 4.57±2.10 2.86±1.83 4.46±3.49
IL-6 7.52±4.99 5.66±4.51 6.72±2.64
5 MIP-1α 44.01±15.07 19.41±15.31** 46.00±3.88
MCP-1 31.76±12.64 12.24±11.88** 30.02±5.39
IL-1α 109.46±41.43 42.75±9.84** 95.58±31.70
IL-1β 15.33±3.02 2.79±2.74** 11.64±6.30
IL-6 13.60±5.99 6.55±1.52 8.50±4.83
6 MIP-1α 47.41±13.03 24.06±5.51* 33.77±12.12
MCP-1 65.17±14.55 19.87±7.93** 45.25±25.79
IL-1α 96.28±26.17 48.34±4.21** 56.24±11.26**
IL-1β 22.38±14.11 7.47±5.12** 15.90±6.84
IL-6 10.56±3.51 6.10±0.51 7.61±1.02
7 MIP-1α 21.98±4.73 25.55±8.85 25.96±2.24
MCP-1 31.90±12.52 20.02±6.40* 31.62±5.48
IL-1α 42.81±7.42 36.05±14.80 50.51±9.97
IL-1β 10.90±3.70 5.31±3.57 5.06±3.50
IL-6 5.63±4.47 ND 1.78±1.75
8 MIP-1α 14.37±2.47 11.22±6.38 12.25±5.03
MCP-1 8.07±3.78 6.87±3.79 8.94±4.56
IL-1α 33.54±3.11 27.58±10.71 30.65±10.41
IL-1β ND ND ND
IL-6 2.75±1.97 ND ND

BALB/c mice were infected with r19F (1×106 TCID50) on day 0 and administered 300μg of anti-G (131-2G) or anti-F (143-6C) protein mAbs on day 3 pi (n=5 mice/group). The lungs were harvested on the indicated days in the Table 3A. The lung homogenates were tested by luminex multiplex assay. Data are means ± SEM.

*

(p≤0.05, ANOVA)

**

(p≤0.001, ANOVA) indicates significant changes in cytokine concentrations for untreated compared to mice receiving the indicated treatments. Results are representative of two independent experiments.