Table 3C.

The effect of anti-G protein mAb 131-2G and anti-F protein 143-6C treatment on Th1 type cytokine levels in r19F RSV infected mice.

		Untreated	mAb 131-2G treated	mAb 143-6C treated
Days (p.i)	Th1 cytokines	pg/gram of lung	pg/gram of lung	pg/gram of lung
4	MIG	132.39±62.18	141.26±63.57	122.39±69.97
	IFN-γ	0.71±0.29	0.49±0.21	0.54±0.17
	IP-10	41.75±16.07	10.79±2.82**	14.28±2.43**
	IL-12	3.44±0.37	2.99±2.67	2.59±1.18
5	MIG	1472.67±668.69	203.25±185.86**	507.30±367.72**
	IFN-γ	82.04±26.35	11.89±5.44**	57.82±21.07*
	IP-10	218.79±105.51	51.59±30.15**	155.49±68.46
	IL-12	3.42±1.40	2.54±1.76	2.62±0.45
6	MIG	1521.28±679.05	2335.77±1016.70	697.94±388.84**
	IFN-γ	62.88±24.23	80.88±43.46	28.61±17.29**
	IP-10	205.40±43.72	232.32±77.85	96.85±41.80**
	IL-12	4.44±2.57	6.58±1.16	1.50±0.52
7	MIG	537.76±34.49	1118.74±296.59**	1069.70±496.54**
	IFN-γ	24.25±7.83	53.37±8.60*	29.27±7.53
	IP-10	60.77±14.30	141.90±36.47**	60.77±19.81
	IL-12	2.63±0.42	5.02±1.95	2.32±0.62
8	MIG	507.39±156.93	408.92±230.97	290.84±244.74
	IFN-γ	7.80±1.24	13.86±3.38	7.71±5.65
	IP-10	29.88±5.25	53.74±13.96*	36.52±20.25
	IL-12	3.43±1.42	4.73±1.70	1.89±3.56

BALB/c mice were infected with r19F (1×10⁶ TCID₅₀) on day 0 and administered 300 μg of anti-G (131-2G) or anti-F (143-6C) protein mAbs on day 3 pi (n=5 mice/group). The lungs were harvested on the indicated days in the Table 3B. The lung homogenates were tested by luminex multiplex assay. Data are means ± SEM.

^*(p≤=0.05, ANOVA)

^**(p≤0.001, ANOVA) indicates significant changes in cytokine concentrations for untreated compared to mice receiving the indicated treatments. Results are representative of two independent experiments.