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. Author manuscript; available in PMC: 2016 May 18.
Published in final edited form as: Mol Psychiatry. 2015 Jan 27;20(12):1499–1507. doi: 10.1038/mp.2014.192

Figure 2. Pre-pulse inhibition is altered in Pvalb/Gad1 mice.

Figure 2

(A) Wt show the expected curve to increased pre-pulse tone intensity, while Tg littermates show a constant minimal response to the entire range of tones presented (p< 0.001), with an already high startle percentage at low tone intensities (p<0.001). (B) 0-maze testing indicates normal preference for closed areas over open areas and similar activity levels. (C) Light-dark box activity shows comparable results in Wt and Tg animals, with the expected avoidance of the lighted area. (D) Both Wt and Tg littermates demonstrate ~70% Y-maze alternations, which is the established number for C57 mice with intact spatial working memory. The overall results suggest that Pvalb/Gad1 Tg mice have an unchanging response to different tone intensity, and this deficit is not a result of altered baseline anxiety or memory disruption.