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. Author manuscript; available in PMC: 2016 May 18.
Published in final edited form as: Mol Psychiatry. 2015 Jan 27;20(12):1499–1507. doi: 10.1038/mp.2014.192

Figure 4. Transgenic animals show impaired fear extinction.

Figure 4

(A) Acquisition of conditioned fear was unaffected in Tg animals, with all animals reaching ~ 80% freezing by the final tone presentation. (B) Extinction percentage over the course of 9 tone presentations with no shock was significantly reduced in transgenic animals compared to Wt littermates (p< 0.001). Extinction was defined as change in freezing behavior from first tone presentation to the last one compared to total freezing at the end of the training phase.