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. Author manuscript; available in PMC: 2016 May 18.
Published in final edited form as: Mol Psychiatry. 2015 Jan 27;20(12):1499–1507. doi: 10.1038/mp.2014.192

Figure 5. Transgenic mice show divergent response to ketamine depending on the dose.

Figure 5

Animals were treated with two sub-anesthetic doses of ketamine (2.5 mg/kg and 5 mg/kg). Total ambulation was unaffected by either dose (A, B). However, rearing behavior was strongly reduced in transgenic animals over Wt (p< 0.0001) (C, E) in response to 2.5 mg/kg ketamine, while a higher dose of 5 mg/kg resulted in a significant increase in cumulative rearing events in the Tg animals (p<0.001) (D, F). These findings argue that NMDA receptor antagonism might have dose-dependent effects on behavioral processes in the context of PVALB+ interneuron dysfunction.