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. 2015 Jul 27;212(8):1239–1254. doi: 10.1084/jem.20150218

Figure 6.

Figure 6.

Genetic ablation of BIRC2 and 3 phenocopies βTRAF2 and βTRAF3 mice. (A) Protein levels of p100 to p52 processing in one WT and one βBIRC2/3 islet isolate were assessed by immunoblotting. A representative of three independent experiments is shown. Histogram data depicts cumulative densitometry relative to β-actin of the three independent experiments. (B) Blood glucose and AUC were measured in 20 WT and 6 βBIRC2/3 HFD-fed mice (16 wk old) after i.p. injection of d-glucose. Data are representative of three independent mouse cohorts tested. **, P < 0.01. (C) Insulin levels and AUC were measured in six WT and six βBIRC2/3 HFD-fed mice (16 wk old) after i.v. injection of d-glucose. Data are representative of three independent mouse cohorts tested. *, P < 0.05. All data are represented as mean ± SEM; p-values were determined using Student’s t test.