Table 1.
Top 15 most highly differentially expressed genes in βTRAF2 and βTRAF3 islets (chow and DIO)
| Genea | Log FCb | Associated functionc | |||
| βTRAF2 chow | βTRAF3 chow | βTRAF2 DIO | βTRAF3 DIO | ||
| Tph1 (tryptophan hydroxylase 1) | - | - | 6.88 | 6.33 | aromatic amino acid family metabolic process, bone remodeling, neuron projection, serotonin synthesis |
| Lrrc55 (leucine rich repeat containing 55) | 3.78 | 2.90 | 5.00 | 5.04 | potassium ion transport, BK channel auxiliary subunit |
| Sftpd (surfactant associated protein D) | 3.12 | 2.28 | 4.07 | 3.15 | phospholipid homeostasis, regulation of phagocytosis, LPS binding |
| Gbp8 (guanylate-binding protein 8) | 3.16 | - | 3.59 | 3.36 | large IFN-γ–induced GTPase |
| Syt10 (synaptotagmin X) | 3.20 | - | 3.53 | 3.24 | regulation of Ca2+-dependent exocytosis, cytoplasmic vesicle |
| Crispld2 (cysteine-rich secretory protein LCCL domain containing 2) | 3.36 | 3.33 | - | 2.68 | extracellular matrix (ECM) component, heparin binding, LPS binding, vesicle transport |
| Hcn1 (hyper-polarization-activated, cyclic nucleotide-gated K+ 1) | 2.75 | 2.40 | 3.36 | 3.24 | potassium ion transport; voltage-gated potassium channel, sensitivity to cAMP |
| Fbxw24 (F-box and WD-40 domain protein 24) | 2.91 | 1.82 | 3.48 | 2.99 | protein coding gene, unknown function |
| Tnfrsf11b (tumor necrosis factor receptor superfamily, member 11b) | - | - | 3.20 | 3.19 | osteoprotegerin (OPG), ECM organisation, regulation of differentiation, negative regulation of bone resorption, decoy receptor for RANKL |
| Matn2 (matrilin 2) | - | - | 3.42 | 2.92 | ECM, formation of filamentous networks, neuron cell migration,Ca2+-binding, |
| Rerg (RAS-like, estrogen-regulated, growth-inhibitor) | 2.13 | 1.56 | 3.30 | 3.04 | RAS superfamily of GTPases, negative regulator of cell growth/proliferation |
| Rasgrp1(RAS guanyl releasing protein 1) | 3.16 | 3.07 | - | 2.93 | GEF activity: activation of Ras and Rho GTPases, Ca2+ binding |
| Fmo1(flavin containing monooxygenase 1) | - | - | 3.16 | 2.55 | drug metabolic process; oxidation-reduction process; NADPH oxidation; organic acid metabolic process |
| Grem2 (gremlin 2 homolog, cysteine knot superfamily (Xenopus laevis)) | 2.19 | 1.49 | 2.54 | 2.28 | regulator of osteoblast differentiation and osteogenesis; cytokine, heparin binding, negative regulation of BMP signaling pathway |
| Gbp4 (guanylate binding protein 4) | 2.29 | 2.44 | large IFN-γ–induced GTPase negative regulation of protein ubiquitination | ||
a
Gene symbol and gene name.
b
Log fold change of differential gene expression in chow and DIO βTRAF2 and βTRAF3 islets.
c
Associated gene function according to DAVID Bioinformatics Database and Mouse Genome Database (MGD) at http://www.informatics.jax.org (September 2014).