Table 2.
Gene ontology and diabetes association of differentially expressed genes in βTRAF2 and βTRAF3 islets (chow and DIO)
| chow | DIO | |
| Gene ontologya | ||
| Regulation of cell growth, proliferation, apoptosis | Adora1, Bcat1, Gfra3, Grem2, Rasgrp1, Rerg, Sftpd, Socs2 | Cish, Fmo1, Igfbp5, Ngfr, Prok1, Tph1, Tnfrsf11b |
| Metabolic processes | Adora1, Bcat1, Grem2, Ogdhl, Slca13, Wipi1 | Fmo1, Ivd, Pde7b, Tph1, Srbd1 |
| Potassium channel component | Hcn1, Kcnk10, Lrrcc55 | Hcn1, Kcnj5 |
| GPCR or GTPase related | Adora1, Gbp4, Gbp10, Gpr126, Gpr182, Penk, Rasgrp1 | Cish, Gbp8, Gpr110, Kcnj5, Rph3a |
| Vesicle-associated | Crispld2, Krtap13-1, Rasgrp1, Wipi1 | Rph3a, Syt10, Tmem2 |
| Diabetes associationb | ||
| associated with type 1 diabetic phenotype in mouse models | Adora1, Bcat1, Gbp4, Gbp10, Hcn1, Rasgrp1 | Fmo1, Ngfr, Tnfrsf11b |
| associated with type 2 diabetic phenotype in mouse models | Adora1, Bcat1, Gfra3, Gpr126, Hcn1, Kcnk10, Penk, Rasgrp1, Rerg, Sftpd, Socs2, Tnfrsf9, Wipi1 | B3galnt1, B3galt1, Cish, Cym, Fmo1, Igfbp5, Kcnj5, Ngfr, Tnfrsf11b |
| associated with T1D in humans | Gbp4, Rasgrp1 | Igfbp5, Tnfrsf11b |
| associated with T2D in humans | Bcat1, Rasgrp1, Sftpd | Adarb2, Igfbp5, Ivd, Kcnj5, Pde7b, Rerg, Rph3a, Slca13, Tnfrsf11b |
a
Genes grouped by associated biological function according to DAVID Bioinformatics Database.
b
Genes associated with T1D and/or T2D in humans; genes associated with a diabetic phenotype in mouse models.