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. 2015 Jul 27;212(8):1219–1237. doi: 10.1084/jem.20141254

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© 2015 Kang et al.

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Figure 9. — Expression of PLD1 and C-IC markers is associated with survival of CRC patients. (A) Relative expression of the indicated genes and miR-4496 in 55 pairs of tumor and adjacent normal tissues from CRC patients was measured by q-RT-PCR. Data were analyzed using the paired t test. Results are representative of at least two independent experiments and are shown as mean ± SEM. (B) In 55 tumor tissues from CRC patients, there was a positive correlation of PLD1 with β-catenin, CD133, CD44, and EpCAM mRNA expression. Spearman’s correlation coefficient (r) is provided with its statistical significance. The red lines represent the best-fit curves. (C) IHC in tumor and adjacent normal tissues from CRC patients. (D) Correlation with survival when patient specimens are segregated according to immunoreactivity of PLD1 and CC-IC surface markers (CD133, CD44, or EpCAM). Kaplan-Meier survival curves of CRC patients (n = 153) are presented. Results are representative of at least two independent experiments. *, P < 0.05; **, P < 0.01; ***, P < 0.001. a.u., arbitrary units. Bars, 100 µm.