Metoclopramide, the only gastrointestinal motility agent widely used in the USA, has a black-box warning for tardive dyskinesia. |
We found that, nonetheless, it is used chronically by at least 28,000 US children, most of whom have at least one health service claim for symptomatic gastroesophageal reflux (GERD). |
This suggests a perception that many US children with symptoms suggestive of GERD are not adequately treated by lifestyle changes and acid suppression. |