Table 3.

Examples of mutation frequencies in (pediatric) tumors

Malignancy	Mutations (range)	Reference
AMLa	0.37 per Mb (0.01–10) of coding sequence	Lawrence et al., Nature 2013
Ependymoma, intracranialb	12.8 ± 10.6 mutations (range 5 to 34) per tumor	Bettegowda et al., Oncotarget 2013
Ependymoma, spinal cordb	12.9 ± 6.4 mutations (range 2 to 23) per tumor	Bettegowda et al., Oncotarget 2013
Ewinga	0.15 per Mb of coding sequence	Brohl et al., PLoS Genet 2014
Glioblastoma multiformeb	1.4 per Mb	Cancer Genome Atlas Research Network, Nature 2008
Glioblastoma, non-brainstem pediatric	23.5 ± 11.2 mutations (range 4–46) per tumor	Bettegowda et al., Oncotarget 2013
MDSb	3 (0–12) mutations per sample in 104 cancer genes	Haferlach et al., Leukemia 2014
Medulloblastoma	8.3 non-synonymous SNVs per sample 0.35 non-silent mutations per megabase	Parsons et al., Science 2011 Pugh et al., Nature 2012
Neuroblastoma	0.60 per Mb of coding regions	Pugh et al., Nature Genet 2013
Rhabdoid cancers	0.19 per Mb (0–0.45) of coding regions	Lee et al., J Clin Invest 2012
Xanthoastrocytoma, pleomorphicb	9.5 ± 8.5 mutations (range 1 to 28) per tumor	Bettegowda et al., Oncotarget 2013

^aTumor samples not specified

^bDescribed in adult tumor samples