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. 2015 Jul 28;9:91. doi: 10.3389/fncom.2015.00091

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Copyright © 2015 Chua, Morrison and Helias.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Determining the calcium spike threshold using EPSP amplitude. (A) Maximum amplitude of the EPSP (without contribution from calcium spikes) evoked by the minimal conductance required to trigger a full calcium spike as a function of τ_e. (B) Firing rates for the neuron with first order kinetics (solid black curve) and with fixed waveform and different calcium thresholds (dashed curves, from blue to green, −20 to −10mV), against different amount of synchronous inputs with τ_e = 0.4ms. (C) Comparison of calcium spike threshold obtained by different approaches: results from simulation with background noise (black); derived from the minimum of the calcium potential slope (blue); derived from the maximum EPSP amplitude of the minimal spike triggering conductance (red).