Table 3.

DNA damage in male rats following treatment with o-anisidine.^a

Dose (mg/kg/day)	% Tail DNA		Tail length (μ)	OTM	# Hedgehogs
	Mean	p-value	Mean	Mean	Mean
Liver
0	0.3 ± 0.06	–	26.9 ± 0.85	0.0 ± 0.01	5.0 ± 2.10
150	0.4 ± 0.11	0.7645	28.9 ± 0.69	0.0 ± 0.01	3.8 ± 0.86
300	0.4 ± 0.15	0.7525	27.5 ± 1.08	0.0 ± 0.01	3.6 ± 0.93
600	0.9 ± 0.22	0.0182b	30.1 ± 1.46	0.1 ± 0.02	2.8 ± 0.66
Trend test p-value	p = 0.4242
EMS	15.9 ± 0.81	<0.0001c	48.5 ± 1.07	2.6 ± 0.18	2.2 ± 0.58
Stomach
0	14.3 ± 2.36	–	42.9 ± 1.58	2.2 ± 0.44	63.4 ± 18.16
150	12.2 ± 2.21	0.7934	43.6 ± 2.52	1.9 ± 0.51	48.2 ± 9.91
300	14.4 ± 0.91	1.0000	45.5 ± 1.92	2.1 ± 0.27	63.0 ± 11.26
600	15.9 ± 2.49	0.9601	46.3 ± 3.43	2.5 ± 0.57	46.0 ± 7.24
Trend test p-value	p = 0.9794
EMS	35.3 ± 1.97	<0.0001c	56.3 ± 1.66	6.9 ± 0.51	126.4 ± 10.34

Abbreviations: EMS = ethyl methanesulfonate (positive control); OTM = olive tail moment.

^aData are presented as mean ± standard error of the mean; % tail DNA, tail length and OTM means are calculated from slide median data.

^bSignificant at p < 0.05.

^cSignificant at p < 0.025.