Table 4.

DNA damage in male rats following treatment with 1,2- dimethylhydrazine dihydrochloride.^a

Dose (mg/kg/day)	% Tail DNA		Tail length (μ)	OTM	# Hedgehogs
	Mean	p-value	Mean	Mean	Mean
Liver
0	0.2 ± 0.04	–	33.2 ± 0.16	0.0 ± 0.01	0.2 ± 0.20
1.56	7.6 ± 0.26	<0.0001b	49.0 ± 1.27	1.4 ± 0.05	9.2 ± 1.88
3.13	13.3 ± 1.17	<0.0001b	55.2 ± 1.52	2.5 ± 0.35	28.6 ± 8.87
6.25	16.5 ± 1.25	<0.0001b	58.8 ± 1.58	3.5 ± 0.39	44.8 ± 7.50
Trend test p-value	p < 0.0001b
EMS	11.6 ± 0.78	<0.0001c	51.0 ± 0.74	2.0 ± 0.13	1.8 ± 0.66
Stomach
0	12.5 ± 1.56	–	44.4 ± 1.35	1.9 ± 0.27	16.0 ± 5.99
1.56	15.0 ± 1.75	0.6883	45.8 ± 1.35	2.3 ± 0.37	24.2 ± 6.94
3.13	11.7 ± 2.29	0.9856	43.8 ± 1.77	1.9 ± 0.48	36.6 ± 10.99
6.25	15.3 ± 2.13	0.6054	45.5 ± 2.43	2.2 ± 0.33	30.2 ± 8.37
Trend test p-value	p = 0.7881
EMS	31.6 ± 1.31	<0.0001c	53.8 ± 2.07	6.0 ± 0.55	62.0 ± 6.99

Abbreviations: EMS = ethyl methanesulfonate (positive control); OTM = olive tail moment.

^aData are presented as mean ± standard error of the mean; % tail DNA, tail length and OTM means are calculated from slide median data.

^bSignificant at p < 0.05.

^cSignificant at p < 0.025.