Table 6.

DNA damage in male rats following treatment with sodium arsenite.^a

Dose (mg/kg/day)	% Tail DNA		Tail Length (μ)	OTM	# Hedgehogs
	Mean	p-value	Mean	Mean	Mean
Liver
0	0.2 ± 0.04	–	32.2 ± 0.93	0.0 ± 0.01	0.0 ± 0.00
7.5	0.3 ± 0.08	0.7407	33.2 ± 0.35	0.0 ± 0.01	0.2 ± 0.20
15.0	0.2 ± 0.02	0.9977	33.0 ± 0.62	0.0 ± 0.00	0.0 ± 0.00
30.0	0.4 ± 0.10	0.1953	34.1 ± 0.57	0.1 ± 0.02	1.4 ± 0.24
Trend test p-value	p = 0.8851
EMS	12.3 ± 1.04	0.0002b	52.7 ± 1.49	2.2 ± 0.25	1.2 ± 0.37
Stomach
0	14.5 ± 2.70	–	44.1 ± 1.84	2.2 ± 0.53	39.0 ± 14.61
7.5	11.2 ± 2.55	0.6551	41.0 ± 2.93	1.6 ± 0.44	41.6 ± 18.62
15.0	11.1 ± 1.36	0.6341	42.9 ± 1.23	1.5 ± 0.24	22.0 ± 7.52
30.0	10.4 ± 2.60	0.4995	41.5 ± 1.97	1.4 ± 0.36	56.8 ± 21.43
Trend test p-value	p = 0.3318
EMS	31.0 ± 1.78	0.0005b	52.5 ± 1.36	5.8 ± 0.50	102.4 ± 15.72

Abbreviations: EMS = ethyl methanesulfonate (positive control); OTM = olive tail moment.

^aData are presented as mean ± standard error of the mean; % tail DNA, tail length and OTM means are calculated from slide median data.

^bSignificant at p < 0.025.