Table 7.

Results of neutral diffusion assays.^a

Dose (mg/kg/day)	% of Cells with LMW DNA
	Liver		Stomach
	Mean	p-value	Mean	p-value
2-AAF
0	3.4 ± 1.33	–	4.2 ± 1.16	–
250	3.2 ± 0.80	0.9992	16.6 ± 4.39	0.0123b
500	4.8 ± 2.18	0.8204	12.8 ± 2.11	0.0905
1000	1.6 ± 0.81	0.6933	5.0 ± 1.84	0.9931
Trend test p-value	p = 0.4002		p = 0.6113
EMS	1.2 ± 0.73	0.1849	6.2 ± 1.46	0.3149
DMN
0	1.8 ± 0.58	–	9.4 ± 2.38	–
0.63	1.2 ± 0.73	0.8588	6.6 ± 1.50	0.5890
1.25	1.2 ± 0.49	0.8588	6.4 ± 1.86	0.5394
2.5	0.8 ± 0.80	0.591	6.2 ± 1.53	0.4914
Trend test p-value	p = 0.5315		p = 0.2689
EMS	1.6 ± 0.60	0.5915	5.2 ± 0.92	0.9310
o-Anisidine
0	3.0 ± 0.00	–	12.2 ± 0.92	–
150	2.8 ± 1.07	0.9956	9.8 ± 1.93	0.7192
300	2.2 ± 0.80	0.8096	12.8 ± 2.87	0.9961
600	2.8 ± 0.80	0.9956	10.4 ± 3.30	0.9144
Trend test p-value	p = 0.8233		p = 0.8179
EMS	2.8 ± 0.49	0.6938	6.4 ± 1.08	0.0034c
1,2-DMH
0	2.0 ± 0.71	–	3.0 ± 1.30	–
1.56	0.8 ± 0.37	0.3185	2.4 ± 0.51	0.9751
3.13	1.8 ± 0.49	0.9881	4.2 ± 1.74	0.8459
6.25	1.2 ± 0.58	0.6185	2.8 ± 1.24	0.9990
Trend test p-value	p = 0.8012		p = 0.5164
EMS	2.6 ± 0.93	0.3104	4.6 ± 0.81	0.1640
Sodium chloride
0	2.4 ± 0.93	–	7.0 ± 1.41	–
500	5.0 ± 2.49	0.4565	10.2 ± 2.33	0.5187
1000	2.8 ± 0.97	0.9945	10.4 ± 2.16	0.4732
2000	4.6 ± 0.51	0.5801	12.6 ± 1.63	0.1346
Trend test p-value	p = 0.4739		p = 0.0576
EMS	4.0 ± 0.77	0.2220	11.8 ± 3.60	0.2495
Sodium arsenite
0	1.2 ± 0.58	–	2.8 ± 1.32	–
7.5	2.6 ± 1.03	0.4857	3.2 ± 1.39	0.9897
15.0	2.2 ± 0.92	0.7136	2.4 ± 0.75	0.9897
30.0	2.8 ± 0.58	0.3831	3.6 ± 1.08	0.9290
Trend test p-value	p = 0.3916		p = 0.8108
EMS	1.6 ± 0.68	0.3333	3.6 ± 0.24	0.2906

Abbreviations: EMS = ethyl methanesulfonate (positive control); LMW = low molecular weight.

^aData are presented as mean ± standard error of the mean.

^bSignificant at p < 0.05.

^cSignificant at p < 0.025.