Table 1.

Causal estimates for a 1 standard deviation (0.13 mmol/L) increase in calcium levels on fasting glucose (mM) using genetic variants from in and around the CASR gene region

	Number of variants	F statistic	Causal estimate	95 % credible interval
All variants	17	3.4	0.022	0.009, 0.035
Variants associated with calcium at p < 0.1	6	7.9	0.028	−0.003, 0.062
Lead variant only	1	30.6	0.044	−0.002, 0.100

Estimates and 95 % credible intervals are estimated from Bayesian likelihood-based method using all 17 measured variants, using the 6 variants associated with calcium in the EPIC-InterAct dataset (p < 0.1), and using the lead variant (rs1801725) only. Partial F statistics are taken from the regression of calcium on the genetic variants in a multivariable regression (with adjustment for age, sex, and centre)