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. 2015 Jun 24;7(7):2354–2370. doi: 10.3390/toxins7072354

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© 2015 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).

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Immunohistochemical comparison of the commercially-available (MC-6053) mAb against SNAP25₁₉₇ vs. Ab635-rMAb in sections of human back skin following treatment with either onabotulinumtoxinA (10U) or vehicle. Confocal images of blood vessels in onabotulinumtoxinA (A,B) and vehicle-treated (E,F) human skin probed with either (A,E) the MC-6053 mAb or (B,F) Ab635-rMAb. Sweat glands in onabotulinumtoxinA (C,D) and vehicle-treated (G,H) human skin probed with either (C,G) the MC-6053 mAb or (D,H) Ab635-rMAb. SNAP25-IR signal is in green. Arrows point to IR-signal within nerve fibers from vehicle treated human skin. BV, blood vessel; CT, connective tissue; SG, sweat gland; Scale bar = 50 μm.