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Schematic presentation of the trigeminovascular system. (modified by Refs. [22,23,26]) Abbrevations: CGRP, calcitonin gene-related peptide; CSD, cortical spreading depression; LC, locus coeruleus; NRM, nucleus raphe magnus; PACAP, pituitary adenylate-cyclase activating polypeptide; PAG, periaqueductal gray matter; SP, substance P; TCC, trigemino-cervical complex; and TRIG, trigeminal ganglion.
