Table 2. Incidence of common adverse events associated with the two dose regimens of gefitinib.

Types of adverse events	H group (n = 48)		S group (n = 48)		P value
	All Grade	Grade 3-4	All Grade	Grade 3-4	All Grade	Grade 3-4
Acne-like rash, n (%)	41 (85.4%)	7 (14.6%)*	33 (68.8%)	0	0.567	0.012*
Diarrhea, n (%)	8 (16.7%)	0	6 (12.5%)	0	0.577	NA
Abnormal aminotransferases level, n (%)	3 (6.3%)	0	1 (2.1%)	0	0.242*	NA

^*Fisher exact test.

H groups refers to escalated gefitinib (500 mg/d), while S group refers to standard dose gefitinib (250 mg/d). NA, not applicable.