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Effect of l-arginine or l-citrulline supplementation on liver tissue amino acid concentrations in control and arginase-treated mice. Liver tissue concentrations during basal and arginase-treated conditions of (A) arginine, (B) citrulline, (C) ornithine and (D) lysine were measured with HPLC. Tissue concentrations are displayed as nmol/g wet tissue). Significance: a p < 0.05 vs. control; b p < 0.05 vs. arginine; c p < 0.05 vs. arginine + arginase; d p < 0.05 vs. citrulline + arginase.
