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. 2015 Jul 28;6:382. doi: 10.3389/fimmu.2015.00382

Figure 3.

Figure 3

Analysis of similarities of CDR3 with the mus musculus proteome. Analysis of IgVH CDR3 sequences in Blastp with the mouse proteome. (A) Exact matches, DTG IgVH CDR3 sequences vs. contiguous sequences in the Mus musculus proteome. (B) DTG CDR3 vs. the mus musculus proteome: Left panel: Hits, i.e. matches with mismatches, denoted as in Figure 1. Right panels: Examples of matches with Microsomal triglyceride transfer protein large subunit isoform 2 precursor, MTTP (12–8 m/4 mm), Phosphoinositide-3-kinase, PIK3 (12–9/3 mm), Serine/threonine-protein phosphatase 5, Ppp5c (11–9 m/2 mm). (C) Hits (IgVH CDR3 vs. mus musculus proteome) normalized to number of IgVH CDR3 sequences from DTG or L2-TG mice. Left: 100% matches; right: matches including mismatches. (D) Anti-dsDNA IgVH CDR3 sequences from DTG with end stage lupus: Examples of hits, sequence matches/mismatches between individual IgVH CDR3 sequences from DTG lupus mouse and the mouse proteome. See also Figure 1 for details on color codes.