Table 4. Kinetic models used for analysis of selected formulations release data.
Formulation code | Zero order (F=kt) | First order (ln (1-F) = - kft) | Higuchi (F= k t0.5) | |||
MRSQ | K | MRSQ | K | MRSQ | K | |
A1 | 0.955 | 0.144 | 0.986 | 0.001 | 0.996 | 2.865 |
A2 | 0.960 | 0.192 | 0.998 | 0.004 | 0.996 | 4.811 |
A3 | 0.973 | 0.143 | 0.997 | 0.002 | 0.999 | 3.558 |
A4 | 0.915 | 0.001 | 0.958 | 0.002 | 0.979 | 0.031 |
A5 | 0.978 | 0.001 | 0.995 | 0.001 | 0.993 | 0.283 |
A6 | 0.979 | 0.003 | 0.982 | 0.004 | 0.983 | 0.008 |
B1 | 0.978 | 0.003 | 0.999 | 0.002 | 0.998 | 0.329 |
B2 | 0.990 | 0.001 | 0.999 | 0.002 | 0.990 | 0.282 |
B3 | 0.960 | 0.001 | 0.990 | 0.002 | 0.998 | 0.033 |
B4 | 0.957 | 0.001 | 0.976 | 0.001 | 0.998 | 0.205 |
B5 | 0.972 | 0.004 | 0.997 | 0.003 | 0.998 | 0.034 |
B6 | 0.954 | 0.001 | 0.974 | 0.001 | 0.994 | 0.184 |
C1 | 0.974 | 0.001 | 0.999 | 0.002 | 0.999 | 0.032 |
C4 | 0.977 | 0.001 | 0.977 | 0.002 | 0.999 | 0.032 |
Adcortyl® | 0.985 | 0.001 | 0.998 | 0.002 | 0.996 | 0.349 |
F denotes fraction of drug released up to time t.